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1.
Heliyon ; 10(8): e29442, 2024 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-38660241

RESUMO

In the dynamic sphere of building energy systems, this study explores advancements in energy integration, storage technologies, management practices, and occupant behavior, assessing sustainable energy practices, including emerging technologies like fuel cells and energy storage systems. It underscores the significance of efficient energy management, considering both renewable and conventional energy mechanisms. The study comprises four key strata: (i) a thorough literature review of recent energy trends, (ii) a comparative study of global energy patents using the World Intellectual Property Organization (WIPO) database, (iii) a comprehensive analysis of building-energy patents, and (iv) expert-guided Analytic Hierarchy Process (AHP) evaluation. These realms encompass five primary sources: (i) energy-efficient building design, (ii) intelligent building automation, (iii) optimizing energy systems integration, (iv) energy storage, and (v) energy management and optimization. Findings reveal energy storage's dominance, with water energy storage and emerging hydrogen technology leading the trajectory. Global energy patent scrutiny underscores China, the United States, and Japan as influential players in optimizing energy markets. The research shapes energy futures, identifies gaps, and drives sustainable energy practices within the built environment, serving as a compass for policymakers and researchers.

2.
Biomimetics (Basel) ; 9(4)2024 Apr 07.
Artigo em Inglês | MEDLINE | ID: mdl-38667230

RESUMO

To objectively quantify the level of visual interference induced by lasers, we developed a biomimetic optical system designed to emulate human vision. This system is based on an optical model of the eye and synthetic imaging principles, allowing it to generate biomimetic optical images that closely mimic human visual perception. Upon exposure to a 532 nm laser, biomimetic optical images were captured under various ambient lighting conditions. By employing a contrast threshold model for human visual target detection and grayscale hierarchy analysis, we devised an evaluation model to quantify the levels of laser-induced visual interference. The bionic images obtained from our experiments, in conjunction with the constructed model, enabled us to assess the degree of laser-induced visual interference. Our results indicate that this system can effectively substitute the human eye when testing laser imaging effects, with the generated bionic images achieving up to 90% concordance with human vision. The proposed evaluation model facilitates the quantitative analysis of laser-induced visual impairment. This apparatus and evaluation model hold significant promise for the precise quantification of laser-induced visual interference levels.

3.
Cell Rep ; 43(4): 114060, 2024 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-38568809

RESUMO

Human cognitive abilities ranging from basic perceptions to complex social behaviors exhibit substantial variation in individual differences. These cognitive functions can be categorized into a two-order hierarchy based on the levels of cognitive processes. Second-order cognition including metacognition and mentalizing monitors and regulates first-order cognitive processes. These two-order hierarchical cognitive functions exhibit distinct abilities. However, it remains unclear whether individual differences in these cognitive abilities have distinct origins. We employ the classical twin paradigm to compare the genetic and environmental contributions to the two-order cognitive abilities in the same tasks from the same population. The results reveal that individual differences in first-order cognitive abilities were primarily influenced by genetic factors. Conversely, the second-order cognitive abilities have a stronger influence from shared environmental factors. These findings suggest that the abilities of metacognition and mentalizing in adults are profoundly shaped by their environmental experiences and less determined by their biological nature.


Assuntos
Cognição , Humanos , Cognição/fisiologia , Adulto , Masculino , Feminino , Meio Ambiente , Adulto Jovem , Interação Gene-Ambiente , Individualidade
4.
R Soc Open Sci ; 11(4): 231686, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38577211

RESUMO

Individual differences in aggressiveness, if consistent across time and contexts, may contribute to the long-term maintenance of social hierarchies in complex animal societies. Although agonistic interactions have previously been used to calculate individuals' positions within a dominance hierarchy, to date the repeatability of agonistic behaviour has not been tested when calculating social rank. Here, we examined the consistency and social relevance of aggressiveness as a personality trait in a free-flying population of greylag geese (Anser anser). For each individual, we quantified (i) aggressiveness using a standardized mirror stimulation test and (ii) dominance ranking based on the number of agonistic interactions won and lost in a feeding context. We found that individual differences in aggressiveness were significantly repeatable and that individuals' aggressiveness predicted their dominance rank position. The flock showed a robust and intermediately steep dominance hierarchy. Social rank was higher in paired birds, males and older birds, and most agonistic interactions occurred between individuals with moderate rank differences. We suggest that selection favours aggressiveness as a personality trait associated with resource acquisition and social rank, whereby a dominance hierarchy may increase the benefits of group living and reduce costs over conflict within dyads.

5.
Front Neurosci ; 18: 1384993, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38638691

RESUMO

MRI-related anxiety in healthy participants is often characterized by a dominant breathing frequency at around 0.32 Hz (19 breaths per minute, bpm) at the beginning but in a few cases also at the end of scanning. Breathing waves at 19 bpm are also observed in patients with anxiety independently of the scanned body part. In patients with medically intractable epilepsy and intracranial electroencephalography (iEEG), spontaneous breathing through the nose varied between 0.24 and 0.37 Hz (~19 bpm). Remarkable is the similarity of the observed breathing rates at around 0.32 Hz during different types of anxiety states (e.g., epilepsy, cancer, claustrophobia) with the preferred breathing frequency of 0.32 Hz (19 bpm), which is predicted by the binary hierarchy model of Klimesch. This elevated breathing frequency most likely reflects an emotional processing state, in which energy demands are minimized due to a harmonic coupling ratio with other brain-body oscillations.

6.
Vaccine ; 2024 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-38627145

RESUMO

The head domain of the hemagglutinin of influenza viruses plays a dominant role in the antibody response due to the presence of immunodominant antigenic sites that are the main targets of host neutralizing antibodies. For the H1 hemagglutinin, five major antigenic sites defined as Sa, Sb, Ca1, Ca2, and Cb have been described. Although previous studies have focused on defining the hierarchy of the antigenic sites of the hemagglutinin in different human cohorts, it is still unclear if the immunodominance profile of the antigenic sites might change with the antibody levels of individuals or if other demographic factors (such as exposure history, sex, or age) could also influence the importance of the antigenic sites. The major antigenic sites of influenza viruses hemagglutinins are responsible for eliciting most of the hemagglutination inhibition antibodies in the host. To determine the antibody prevalence towards each major antigenic site, we evaluated the hemagglutination inhibition against a panel of mutant H1 viruses, each one lacking one of the "classic" antigenic sites. Our results showed that the individuals from the Stop Flu NYU cohort had an immunodominant response towards the sites Sb and Ca2 of H1 hemagglutinin. A simple logistic regression analysis of the immunodominance profiles and the hemagglutination inhibition titers displayed by each donor revealed that individuals with high hemagglutination inhibition titers against the wild-type influenza virus exhibited higher probabilities of displaying an immunodominance profile dominated by Sb, followed by Ca2 (Sb > Ca2 profile), while individuals with low hemagglutination inhibition titers presented a higher chance of displaying an immunodominance profile in which Sb and Ca2 presented the same level of immunodominance (Sb = Ca2 profile). Finally, while age exhibited an influence on the immunodominance of the antigenic sites, biological sex was not related to displaying a specific immunodominance profile.

7.
Int J Occup Saf Ergon ; : 1-11, 2024 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-38628033

RESUMO

This study examined the reliability of respirators using hierarchical analysis and multicriteria decision-making. The hierarchical structure, which consists of three assessment criteria and six product assemblies as decision possibilities, reveals that the priority of evaluation criteria follows the trend of cost, complexity and technology. Face-piece, triple-piece and visor assemblies have the highest failure rate, according to an analysis of product reliability at the assembly level. However, according to the analysis at the parts level, the most likely failures are found in the face-piece, upper and lower visor frames, visor, head-harness, exhalation valve disc and exhalation valve seat. In addition, the Weibull distribution function (with a shape parameter >1) can be utilized to predict product reliability. Among the six defined product assemblies, according to the sensitivity analysis, the overall weight of the triple-piece assembly and the visor assembly has the most sensitivity to changes in the priority of evaluation criteria.

8.
Front Vet Sci ; 11: 1299550, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38566752

RESUMO

Sheep pain is an animal welfare issue monitored based on behavioral responses, including appetite. Dominant (alpha) males have priority for accessing limited feed resources, however, the effects of pain on feed interest in members of a group with defined social hierarchy are unknown. Our objective was to investigate effects of acute post-orchiectomy pain on alpha rams' interest in accessing a limited feed resource. Eighteen rams were randomly housed in pens of 3 rams. After acclimation, the first 5-d (consecutive) battery of a behavior test was performed. In this test, 180 g of the regular diet concentrate was placed in a portable trough in the center of the pen; this feed was supplemental to the diet and represented a limited, albeit strongly preferable feed resource. Rams were filmed for 5 min after the feed introduction. Hierarchical levels (alpha, beta, and gamma) were defined based on the social hierarchical index according to higher initiator and lower receptor agonistic behaviors from the social network analyses. After 15 d, a second 5-d behavioral test battery was repeated. On the following day, alpha rams were castrated. Flunixin meglumine was given immediately before surgery and a final behavioral test was performed 8 h post-orchiectomy, concurrent with an expected peak in postoperative pain. For all recordings, the latency, frequency, and duration of time that each ram had its mouth inside the feed trough were recorded, and the Unesp-Botucatu sheep acute pain scale pain scale (USAPS) was applied. The social hierarchical index was highest in alpha rams, followed by beta and gamma. The pain scores were statistically equivalent across the 11 evaluation days for beta and gamma rams, whereas there was an increase in the final evaluation for alpha. There was no difference in latency, frequency, and duration between alpha, beta, and gamma rams across evaluations. We concluded that acute post-orchiectomy pain did not decrease alpha rams' interest in accessing limited feed. Routine feeding offers a valuable chance to detect pain-related behavior using the USAPS in rams. However, dominance may confound appetite-related behaviors in assessing acute pain, as alpha rams' interest in limited feed remained unaffected by the pain.

9.
Psychol Med ; : 1-10, 2024 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-38571298

RESUMO

BACKGROUND: Extensive research has explored altered structural and functional networks in major depressive disorder (MDD). However, studies examining the relationships between structure and function yielded heterogeneous and inconclusive results. Recent work has suggested that the structure-function relationship is not uniform throughout the brain but varies across different levels of functional hierarchy. This study aims to investigate changes in structure-function couplings (SFC) and their relevance to antidepressant response in MDD from a functional hierarchical perspective. METHODS: We compared regional SFC between individuals with MDD (n = 258) and healthy controls (HC, n = 99) using resting-state functional magnetic resonance imaging and diffusion tensor imaging. We also compared antidepressant non-responders (n = 55) and responders (n = 68, defined by a reduction in depressive severity of >50%). To evaluate variations in altered and response-associated SFC across the functional hierarchy, we ranked significantly different regions by their principal gradient values and assessed patterns of increase or decrease along the gradient axis. The principal gradient value, calculated from 219 healthy individuals in the Human Connectome Project, represents a region's position along the principal gradient axis. RESULTS: Compared to HC, MDD patients exhibited increased SFC in unimodal regions (lower principal gradient) and decreased SFC in transmodal regions (higher principal gradient) (p < 0.001). Responders primarily had higher SFC in unimodal regions and lower SFC in attentional networks (median principal gradient) (p < 0.001). CONCLUSIONS: Our findings reveal opposing SFC alterations in low-level unimodal and high-level transmodal networks, underscoring spatial variability in MDD pathology. Moreover, hierarchy-specific antidepressant effects provide valuable insights into predicting treatment outcomes.

10.
World J Clin Cases ; 12(9): 1555-1559, 2024 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-38576735

RESUMO

Evidence-based practice (EBP) has been the gold standard in healthcare for nearly three centuries and aims to assist physicians in providing the safest and most effective healthcare for their patients. The well-established hierarchy of evidence lists systematic reviews and meta-analyses at the top however these methodologies are not always appropriate or possible and in these instances case-control studies, case series and case reports are utilised to support EBP. Case-control studies allow simultaneous study of multiple risk factors and can be performed rapidly and relatively cheaply. A recent example was during the Coronavirus pandemic where case-control studies were used to assess the efficacy of personal protective equipment for healthcare workers. Case series and case reports also play a role in EBP and are particularly useful to study rare diseases such as inflammatory bowel disease in transgender and gender non-conforming individuals. They are also vital in generating and disseminating early signals and encouraging further research. Whilst these methodologies have weaknesses, particularly with regards to bias and loss of patient confidentiality for rare pathologies, they have an important part to play in EBP and when appropriately utilised can significantly impact upon clinical practice.

11.
Waste Manag Res ; : 734242X241242682, 2024 Apr 06.
Artigo em Inglês | MEDLINE | ID: mdl-38581268

RESUMO

Hospitals need to identify issues of greater importance on waste management because the implementation of many different strategies may lead to an unconscious increase in costs. Accordingly, the purpose of this study is to define the most effective waste management strategies in the service industry. For this purpose, a novel fuzzy decision-making model is proposed that has two different stages. In this context, six JCI-based indicators are weighted by using sine trigonometric fuzzy Decision Making Trial and Evaluation Laboratory (DEMATEL) methodology. Additionally, a comparative evaluation has also been conducted with sine trigonometric fuzzy Criteria Importance Through Intercriteria Correlation (CRITIC) technique to check the reliability of the findings. On the other hand, five different strategy alternatives are selected by considering the principles of the integrated waste management hierarchy approach. These items are evaluated by considering sine trigonometric fuzzy Technique for Order Preference by Similarity (TOPSIS). On the other side, these factors are also ranked with the help of sine trigonometric fuzzy Additive Ratio Assessment (ARAS) to test the consistency of the results. The main contribution is that prior strategies can be presented to the hospitals to have appropriate waste management process by defining the most important factors. Criteria weighting and alternative ranking results are the same in all combinations. Therefore, it is seen that the proposed model creates coherent and consistent results. It is defined that efficient storage of waste is the key issue to have effective waste management process. Moreover, 'reduce' is found as the most critical stage of this process.

12.
Curr Biol ; 2024 Apr 18.
Artigo em Inglês | MEDLINE | ID: mdl-38657610

RESUMO

Flies groom in response to competing mechanosensory cues in an anterior-to-posterior order using specific legs. From behavior screens, we identified a pair of cholinergic command-like neurons, Mago-no-Te (MGT), whose optogenetic activation elicits thoracic grooming by the back legs. Thoracic grooming is typically composed of body sweeps and leg rubs in alternation, but clonal analysis coupled with amputation experiments revealed that MGT activation only commands the body sweeps: initiation of leg rubbing requires contact between the leg and thorax. With new electron microscopy (EM) connectome data for the ventral nerve cord (VNC), we uncovered a circuit-based explanation for why stimulation of posterior thoracic mechanosensory bristles initiates cleaning by the back legs. Our previous work showed that flies weigh mechanosensory inputs across the body to select which part to groom, but we did not know why the thorax was always cleaned last. Here, the connectome for the VNC enabled us to identify a pair of GABAergic inhibitory neurons, UMGT1, that receives diverse sensory inputs and synapses onto both MGT and components of its downstream circuits. Optogenetic activation of UMGT1 suppresses thoracic cleaning, representing a mechanism by which mechanosensory stimuli on other body parts could take precedence in the grooming hierarchy. We also anatomically mapped the pre-motor circuit downstream of MGT, including inhibitory feedback connections that may enable rhythmicity and coordination of limb movement during thoracic grooming. The combination of behavioral screens and connectome analysis allowed us to identify a neural circuit connecting sensory-to-motor neurons that contributes to thoracic grooming.

13.
BMC Oral Health ; 24(1): 488, 2024 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-38658882

RESUMO

BACKGROUND: Orthodontics is a common treatment for malocclusion and is essential for improving the oral health and aesthetics of patients. Currently, patients often rely on the clinical expertise and professional knowledge of doctors to select orthodontic programs. However, they lack their own objective and systematic evaluation methods to quantitatively compare different programs. Therefore, there is a need for a more comprehensive and quantitative approach to selecting orthodontic treatment plans, aiming to enhance their scientific validity and effectiveness. METHODS: In this study, a combination of the analytic hierarchy process (AHP) and semantic analysis was used to evaluate and compare different orthodontic treatment options. An AHP model and evaluation matrix were established through thorough research and semantic analysis of patient requirements. This model considered various treatment factors. Expert panels were invited to rate these factors using a 1-9 scale. The optimal solution was determined by ranking and comparing different orthodontic treatment plans using the geometric mean method to calculate the weights of each criterion. RESULTS: The research indicates a higher preference for invisible correction compared to other orthodontic solutions, with a weight score that is 0.3923 higher. Factors such as comfort and difficulty of cleaning have been given significant attention. CONCLUSION: The Analytic Hierarchy Process (AHP) method can be utilized to effectively develop orthodontic treatment plans, making the treatment process more objective, scientific, and personalized. The design of this study offers strong decision support for orthodontic treatment, potentially improving orthodontic treatment outcomes in clinical practice and ultimately enhancing oral health and patients' quality of life.


Assuntos
Má Oclusão , Ortodontia Corretiva , Humanos , Ortodontia Corretiva/métodos , Má Oclusão/terapia , Planejamento de Assistência ao Paciente , Tomada de Decisões , Tomada de Decisão Clínica , Técnicas de Apoio para a Decisão
14.
Ying Yong Sheng Tai Xue Bao ; 35(3): 780-788, 2024 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-38646766

RESUMO

The primary goal of national parks is to protect ecological environment, but also with the functions of scientific research, education, and recreation. Aiming for the realization of universal sharing, we used the analytic hierarchy process (AHP) to construct an ecotourism suitability evaluation system by selecting four factors, including landscape resources, ecological environment carrying capacity, recreation utilization capacity and social condition, taking Xiaoxiangling area of Giant Panda National Park and the surrounding communities as an example. We evaluated the ecotourism suitability based on GIS, and conducted a questionnaire survey of tourists, to propose suggestions on the functional zoning in terms of ecotourism suitability and subjective choice preferences of tourists. The results showed that the ecotourism suitability of the evaluation area could be classified into five levels. The most suitable areas were located nearby the natural landscape resources and far away from the core conservation area, and the least suitable areas distributed at the edge of the core conservation area. According to the results of suitability analysis, the evaluation area was divided into suitable development area, moderate development area, and restricted development area. Combined with the tourist preferences, we divided the recreational activities in the evaluation area into seven activities, namely, ecotourism, eco-camping, science education, leisure vacation, agricultural and animal husbandry culture experience, eco-education, and mountain adventure. These findings could help provide suitable services for different tourists and offer reference for the ecotourism developmental planning of the Xiaoxiangling area of the Giant Panda National Park.


Assuntos
Conservação dos Recursos Naturais , Ecossistema , Sistemas de Informação Geográfica , Parques Recreativos , Ursidae , Animais , China , Recreação
15.
Front Psychol ; 15: 1344033, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38650907

RESUMO

According to Loorits, if we want consciousness to be explained in terms of natural sciences, we should be able to analyze its seemingly non-structural aspects, like qualia, in structural terms. However, the studies conducted over the last three decades do not seem to be able to bridge the explanatory gap between physical phenomena and phenomenal experience. One possible way to bridge the explanatory gap is to seek the structure of consciousness within consciousness itself, through a phenomenal analysis of the qualitative aspects of experience. First, this analysis leads us to identify the explanandum concerning the simplest forms of experience not in qualia but in the unitary set of qualities found in early vision. Second, it leads us to hypothesize that consciousness is also made up of non-apparent parts, and that there exists a hidden structure of consciousness. This structure, corresponding to a simple early visual experience, is constituted by a Hierarchy of Spatial Belongings nested within each other. Each individual Spatial Belonging is formed by a primary content and a primary space. The primary content can be traced in the perceptibility of the contents we can distinguish in the phenomenal field. The primary space is responsible for the perceptibility of the content and is not perceptible in itself. However, the phenomenon I refer to as subtraction of visibility allows us to characterize it as phenomenally negative. The hierarchical relationships between Spatial Belongings can ensure the qualitative nature of components of perceptual organization, such as object, background, and detail. The hidden structure of consciousness presents aspects that are decidedly counterintuitive compared to our idea of phenomenal experience. However, on the one hand, the Hierarchy of Spatial Belongings can explain the qualities of early vision and their appearance as a unitary whole, while on the other hand, it might be more easily explicable in terms of brain organization. In other words, the hidden structure of consciousness can be considered a bridge structure which, placing itself at an intermediate level between experience and physical properties, can contribute to bridging the explanatory gap.

16.
Front Psychol ; 15: 1300686, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38425551

RESUMO

The sustainable development of serious games dedicated to Chinese cultural heritage faces challenges due to the lack of prolonged user engagement and iterative optimization based on long-term user feedback. This situation not only hinders the sustainable growth of these games but also limits the transmission of Chinese cultural heritage, a problem that demands urgent attention yet remains under-acknowledged. This study synthesizes literature to unearth user needs from three dimensions: motivational use, quality requirements of games, and continuous usage intention. It identifies 14 influential factors, including cognitive satisfaction, immersion satisfaction, and achievement satisfaction. Drawing from the User Experience Rubric for Educational Games-CH (UEREG-CH) evaluation rubric and the Delphi method, these factors are expanded into an evaluation system model comprising six primary indicators, 14 secondary indicators, and 38 tertiary indicators. The analytic hierarchy process (AHP) is utilized for expert scoring to assign weights to each indicator. This is combined with the fuzzy comprehensive evaluation method to arrive at a final user score of Z = 3.4228, indicating that the evaluation rubric is close to 'good' and has received positive user feedback. Ultimately, this generates an evaluation rubric tailored to the specific context of serious games for cultural heritage. By integrating qualitative and quantitative methods, this paper confirms the scientific and rational nature of the evaluation rubric. The study aims to establish a user-approved rubric that encourages continuous usage intention, thereby providing effective guidance for game developers and assisting users in selecting appropriate games, while also addressing the theoretical gap in the field of evaluation for serious games related to cultural heritage.

17.
Heliyon ; 10(5): e27389, 2024 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-38463822

RESUMO

Bone marrow aspiration is a crucial medical procedure to obtain bone marrow samples for diagnosis and treatment. However, traditional bone marrow aspiration needles face several challenges such as operational difficulties, inadequate sample acquisition, and patient discomfort. To address these issues, we aimed to design a bone marrow aspiration needle product by using fuzzy analytic hierarchical process (FAHP). The FAHP method was used to identify key factors in the design of the bone marrow aspiration needle, including technicality, usage, and application characteristics. The importance weights and priorities of each factor were determined through questionnaires and interviews with experts. A new bone marrow aspiration needle product was developed based on the results of the FAHP. The new product design considers the weights and priorities assigned to key factors, resulting in improved convenience during operation and a higher success rate of sample acquisition. This was achieved by optimising the structure and material selection of the needle. This study presents a novel bone marrow puncture needle product that effectively integrates the importance and priority of the key factors. It successfully enhances operational performance and patient experience, thereby offering an innovative solution to improve the success rate and therapeutic effect of bone marrow punctures.

18.
Anim Cogn ; 27(1): 12, 2024 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-38429548

RESUMO

There are indications that companion dogs of multi-dog households form a hierarchy, maintained by formal and agonistic dominance. Although it was found that the behaviour of dogs depends on their rank in several contexts, so far, the assessment of their rank itself has been based on owner-completed questionnaires. With this research we endeavoured to find associations between rank scores from the Dog Rank Assessment Questionnaire (DRA-Q) and cohabiting dogs' behaviour in a competitive test (Toy Possession test-32 dog pairs) and a non-competitive, citizen science scenario (Greeting test-20 dog pairs). Based on the grabbing the toy first and keeping the toy at the end variables, the dogs' rank score provided a reliable indication of the dominant and subordinate dogs' behaviour in the Toy Possession test. Similarly, the occurrence of dominant and submissive behaviours in the Greeting Test showed a good match with the agonistic and leadership subscores of the composite rank score from the DRA-Q. Our results provide a pioneering case for validating a questionnaire-based rank scoring method with biologically meaningful behavioural tests in the case of companion dogs. The finer analysis of the results highlighted that in the case of a multi-question scoring system, some components might provide more effective prediction of the dogs' rank-related behaviour in some situations, while other components are more relevant in others, with traits related to agonistic dominance having relevance across contexts.


Assuntos
Comportamento Animal , Animais de Estimação , Cães , Animais , Predomínio Social , Vínculo Humano-Animal , Inquéritos e Questionários
19.
Expert Opin Ther Pat ; : 1-18, 2024 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-38446009

RESUMO

INTRODUCTION: Vibrio cholerae bacteria cause an infection characterized by acute diarrheal illness in the intestine. Cholera is sustained by people swallowing contaminated food or water. Even though symptoms can be mild, if untreated disease becomes severe and life-threatening, especially in low-income countries. AREAS COVERED: After a description of the most recent literature on the pathophysiology of this infection, we searched for patents and literature articles following the PRISMA guidelines, filtering the results disclosed from 2020 to present. Moreover, some innovative molecular targets (e.g., carbonic anhydrases) and pathways to counteract this rising problem were also discussed in terms of design, structure-activity relationships and structural analyses. EXPERT OPINION: This review aims to cover and analyze the most recent advances on the new druggable targets and bioactive compounds against this fastidious pathogen, overcoming the use of old antibiotics which currently suffer from high resistance rate.

20.
Proc Biol Sci ; 291(2018): 20231729, 2024 Mar 13.
Artigo em Inglês | MEDLINE | ID: mdl-38471548

RESUMO

Animals rely on a balance of personal and social information to decide when and where to move next in order to access a desired resource. The benefits from cueing on conspecifics to reduce uncertainty about resource availability can be rapidly overcome by the risks of within-group competition, often exacerbated toward low-ranked individuals. Being obligate soarers, relying on thermal updraughts to search for carcasses around which competition can be fierce, vultures represent ideal models to investigate the balance between personal and social information during foraging movements. Linking dominance hierarchy, social affinities and meteorological conditions to movement decisions of eight captive vultures, Gyps spp., released for free flights in natural soaring conditions, we found that they relied on social information (i.e. other vultures using/having used the thermals) to find the next thermal updraught, especially in unfavourable flight conditions. Low-ranked individuals were more likely to disregard social cues when deciding where to go next, possibly to minimize the competitive risk of social aggregation. These results exemplify the architecture of decision-making during flight in social birds. It suggests that the environmental context, the context of risk and the social system as a whole calibrate the balance between personal and social information use.


Assuntos
Falconiformes , Humanos , Animais , Aves , Predomínio Social
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